Capacity of small molecules to form β-cyclodextrin inclusion complexes
نویسندگان
چکیده
منابع مشابه
Study to explore the mechanism to form inclusion complexes of β-cyclodextrin with vitamin molecules
Host-guest inclusion complexes of β-cyclodextrin with two vitamins viz., nicotinic acid and ascorbic acid in aqueous medium have been explored by reliable spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser of the guest molecules. Job's plots have been drawn by UV-visible spectroscopy to confirm the 1:1 stoichiometry of the host-guest assembly....
متن کاملThermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin
One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...
متن کاملEvaluation of Some Methods for Preparing Glipizide-β-Cyclodextrin Inclusion Complexes
Glipizide has been found to form inclusion complexes with β-cyclodextrin (β-CD) in solution and in solid state. The present study was undertaken to determine a suitable method for scaling up glipizide-β-CD inclusion complex formation and to evaluate the effect of some parameters on the efficiency of complexation. The solid inclusion complexes of glipizide and β-CD were prepared at a molar...
متن کاملPreparation and Evaluation of Silymarin β-cyclodextrin Molecular Inclusion Complexes
Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...
متن کاملInclusion Complexes of Promethazine with Monochlorotriazinyl-β-cyclodextrin
Formation of inclusion complexes of monochlorotriazinyl-β-cyclodextrin with promethazine was studied, for establishing the optimal conditions of their formation, in view of subsequent grafting on cellulose textiles with potential medicinal use. The infrared spectral study of inclusion in solid state indicated that the complex can be even formed by physically mixing the two substances. By the co...
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ژورنال
عنوان ژورنال: Supramolecular Chemistry
سال: 2009
ISSN: 1061-0278,1029-0478
DOI: 10.1080/10610270902980630